Another immunoregulatory function of RNF5 is to mediate ubiquitin-dependent degradation of stimulator of interferon genes (STING) and negatively regulate antiviral innate immune responses.31 Of note, STING is a central DNA sensing component that mediates DC activation in tumor microenvironment and has been actively exploited in cancer immunotherapy.32,33 Whether RNF5 deletion in DCs promotes DC activation and T cell priming in antitumor immunity is yet to be investigated. Here, RNF5 is linked to cancer.