SQSTM1 and cancer: Selective autophagy employs specific cargo adapters to target proteins, protein complexes, or organelles for degradation.127 One major cargo adapter of selective autophagy is p62 (also called SQSTM1), which targets ubiquitinated cargos for autophagic degradation.127 Silencing of p62 or genetic deletion of major autophagy components in CD4 T cells enhances PU.1 expression and promotes Th9 differentiation and antitumor immunity in different mouse cancer models.126