GEM and cholangiocarcinoma: To disclose the possible role of lncRNAs in chemoresistance of CCA cells, two gemcitabine-resistant CCA cell lines (HuCCT1-Gem and SNU-245-Gem) were established by exposing the parental HuCCT1 and SNU-245 cells to increasing concentrations of gemcitabine for 8 months.