In colon cancer, conditional ablation of BCL9/BCL9L suppresses the expression of stem cell markers and generation of ulcerated colon epithelium in intestinal epithelium, and transcriptional profiles indicates that BCL9/BCL9L regulates a subset of Wnt/β-Catenin target genes controlling EMT and stemness30. The gene discussed is BCL9L; the disease is malignant colon neoplasm.