Since it is obvious that KDM5A has a significant causal or strongly prognostic effect on SARC, so, the expression level of KDM5A in collected twenty-one paired osteosarcoma and adjacent normal tissues (Enneking staging, I–II stage: n = 10, III stage: n = 11) was detected and evaluated by using immunohistochemistry (IHC) staining (Fig. 1C). This evidence concerns the gene KDM5A and osteosarcoma.