SIX1 and congenital rubella syndrome: Of note, sagittal suture fusion was present in all eight affected individuals, an unusual pattern as monogenic types of CRS more commonly involve the coronal sutures.11 In four subjects, the sagittal synostosis was present together with the involvement of both lambdoid sutures (‘Mercedes-Benz’ pattern), a rare combination of suture fusions present in 23 of the 1629 probands screened for SIX1 mutations (online supplemental table S2).