In a cohort of 4250 unselected CRS cases treated in a single department, only 39 patients were diagnosed with combined sagittal and bilambdoid synostosis12; our finding that 4 of 8 patients with SIX1 pathogenic variants exhibited the Mercedes-Benz pattern represents a significant enrichment (p<10−6, two-tailed Fisher’s exact test). The gene discussed is SIX1; the disease is congenital rubella syndrome.