In keeping with our data, γδ T cell and NK cell ligands MICA, MICB and ULBP1-3 have all been shown to be repressed mainly by histone deacetylation and partly by DNA methylation.34 Treatment of cancer cell lines with DNMTi alone or in combination with HDACi resulted in upregulation of MICA and MICB, which resensitized tumor cells to NK cell attack in vitro. This evidence concerns the gene MICA and cancer.