Following 12 weeks of CS exposure, the evidence of accumulation of inflammatory cell infiltrated in peribronchial and perivascular tissues as well as the parenchyma, goblet cell hyperplasia, expression of p65, and the development of emphysema, was consistent to that of previously published studies [62, 94] indicating the development of COPD by CS inhalation. The gene discussed is RELA; the disease is chronic obstructive pulmonary disease.