Our study on microarray also revealed that CS significantly regulated the pathways related to COPD and upregulated genes related to inflammation including NFKB1, p65, and protein kinase Cζ (PRKCZ), while treatment with hUC-MSC-EVs and hUC-MSCs were observed to reverse these CS-induced gene expression effects. The gene discussed is NFKB1; the disease is chronic obstructive pulmonary disease.