A novel in vivo CRISPR/Cas9 delivery system constructed by R8-dGR-modified cationic liposomes penetrates deeply into PC spheroids and enhances the antiproliferation and antimetastatic effect of paclitaxel in the BxPC-3 PC model through downregulation of HIF-1α and its downstream molecules VEGF and MMP9, without severe toxicity induced in vivo [250]. Here, MMP9 is linked to pachyonychia congenita.