Unlike the inhibitory effects of vascular normalization strategies on angiogenic factors, the protein phosphatase 2A (PP2A) inhibitor LB-100 increases microvessel density and blood perfusion via HIF-1α-VEGF-mediated angiogenesis to enhance the cytotoxicity of doxorubicin in PC models [229]. Here, HIF1A is linked to pachyonychia congenita.