The prolyl 4-hydroxylase subunit alpha 1 (P4HA1) is critically involved in the glycolytic phenotype of pancreatic ductal adenocarcinoma (PDAC) cells, which can be transactivated by HIF-1α under hypoxic condition and further enhances HIF-1α stabilization [31]. The gene discussed is HIF1A; the disease is pancreatic ductal adenocarcinoma.