Conceivably, CXCL12γ-controlled adhesion serves to retain MM cells in close physical contact with the BMSCs, providing MM cells with growth and survival signals through integrin receptors as well as with access to short-range growth and survival factors, such as Wnts and vascular endothelial growth factor [45, 46], which may act in concert to mediate drug resistance. The gene discussed is VEGFA; the disease is Miyoshi myopathy.