However, recombinant CXCL12γ (or CXCL12α)-induced adhesion to VCAM-1-coated plastic did not protect MM cells against bortezomib-induced cell death (Additional file 1: Figure S6), indicating that integrin-mediated cell adhesion per se is not sufficient to instigate bortezomib resistance. The gene discussed is VCAM1; the disease is Miyoshi myopathy.