Notably, MM cells express high levels of the HSPG syndecan-1, which is crucial for MM cell survival [47, 48] and promotes Wnt-mediated cell proliferation [30] as well as hepatocyte growth factor (HGF), FGF, epidermal growth factor (EGF), and a proliferation-inducing ligand (APRIL)-mediated signaling [49–51]. This evidence concerns the gene HGF and Miyoshi myopathy.