Further assessing the spatial relationship between ALDH1+ cells (ALDH1 has been identifed to be a functional marker for the epithelial-like CSCs derived from different cancer types) and areas of hypoxia within TNBC tumors, we observed high-density areas of ALDH1+ cells within hypoxic regions of tumors from Bevacizumab-treated mice, in contrast, ALDH1+ cells were scattered throughout tumors from control animals and the ALDH1+ staining was junior (Fig. 5c). Here, ALDH1A1 is linked to cancer.