Herein, we analyzed CSF samples from a validation cohort in the Korean Brain Aging Study for the Early Diagnosis and Prediction of Alzheimer’s Disease (KBASE-V study) using a fully automated immunoassay Lumipulse G and two manual immunoassay platforms: xMAP-Luminex INNOBIA-AlzBio3 multiplex assay (Luminex) and ELISA with INNOTEST kit (INNOTEST) for Aβ42, Aβ40 (only for INNOTEST and Lumipulse G), t-tau, or p-tau. This evidence concerns the gene MAPT and early-onset autosomal dominant Alzheimer disease.