Furthermore, using PET-based cutoffs, we observed that Aβ42 and ratios (i.e., Aβ42/Aβ40, t-tau/Aβ42, and p-tau/Aβ42) measured by Lumipulse predicted progression of cognitive decline and deterioration of daily living over 3 years in our subgroup of 139 participants, after adjusting for covariates. The gene discussed is MAPT; the disease is Mental deterioration.