Anthracycline-containing regimens, for example CHOP (cyclophosphamide, doxorubicin, vincristine, prednisone) and CHOP plus etoposide (CHOEP), were commonly conducted in the first-line treatment of PTCL which have remained as the recommended approaches for most PTCL subtypes except for NK/T cell lymphoma in the first-line setting. Here, DDIT3 is linked to mature T-cell and NK-cell non-Hodgkin lymphoma.