A recent preclinical study of colorectal cancer cells [63] revealed that the combined application of Propionibacterium freudenreichii and TNF-related apoptosis-inducing ligand (TRAIL) increased proapoptotic gene expression and decreased antiapoptotic gene expression in those cells, suggesting that P. freudenreichii may be useful as an adjuvant for TRAIL-based colorectal cancer therapy. Here, TNFSF10 is linked to colorectal cancer.