TP53 and non-small cell lung carcinoma: Beyond that, our results demonstrated that CDCA4 had the ability of inhibiting metastasis in NSCLC cells in a p53-independent manner, as the two NSCLC cell lines we chose to carry out experiments were A549, which contain wild p53 type, and H1299, in which p53 is deficient, and results suggested that CDCA4 had the same function in inhibiting migration and invasion in both cell lines.