To explore if CARM1 was the downstream functional molecule through which CDCA4 could control NSCLC migration, invasion and autophagy, we performed rescue assay via knocking down CARM1 with specific siRNA in both CDCA4 overexpressing cells and CDCA4 knocking down cells to see alterations in migration and autophagy. Here, CDCA4 is linked to non-small cell lung carcinoma.