TCF7L2 and cancer: Similarly, a cross-sectional analysis of the Malmö Diet and Cancer Study Cardiovascular Sub-cohort, indicated that a higher fiber intake was associated with a reduced risk of type 2 diabetes and lower HbA1C levels in individuals with the CC genotype of the TCF7L2 rs7903146 variant; however, individuals carrying T-risk allele lacked this protective effect [11].