TCF7L2 and metabolic syndrome: Therefore, the aim of the current study was to investigate (1) the association of nut consumption with the MetS risk based on the TCF7L2 rs7903146 and rs12255372 genotypes, and (2) whether these associations are modified according to weight change during follow-up (≥ or < 7%) among adult participants of this population-based study, over a median 8.9-year of follow-up.