In line with our findings suggesting risk-lowering effects of nut consumption on MetS in participants with genotypes CT + TT rs7903146 and GT + TT rs12255372 risk, data have reported a protective effect of other dietary compounds, as well as dietary patterns, against type 2 diabetes risk in subjects carrying the risk-allele T of the TCF7L2 variants [39–41]. Here, TCF7L2 is linked to metabolic syndrome.