To uncover specific gene expression signature of KRAS-oncogene-driven lung cancer, we analyzed transcriptional expression profiles of normal lung tissues and KRAS-mutant lung tumor tissues based on GEO datasets (GSE18784, GSE49200), respectively, and identified differentially expressed genes (DEGs) with statistical difference (P < 0.05) between normal and tumor tissues. This evidence concerns the gene KRAS and lung carcinoma.