In our study, we found that SDPR expression was not only decreased in KRAS-mutant NSCLC cells, and KRAS-driven murine tumor from GEMMs, but also downregulated in human NSCLC specimens based on GEO datasets, TCGA datasets, and lung adenocarcinoma tissue array (Fig. 2a–g). The gene discussed is CAVIN2; the disease is lung adenocarcinoma.