In our study, we found that SDPR expression was not only decreased in KRAS-mutant NSCLC cells, and KRAS-driven murine tumor from GEMMs, but also downregulated in human NSCLC specimens based on GEO datasets, TCGA datasets, and lung adenocarcinoma tissue array (Fig. 2a–g). This evidence concerns the gene CAVIN2 and non-small cell lung carcinoma.