It is well known that IL-6 can play two important roles in the pathogenesis of hepatitis B, can protect the liver from virus infections by stimulating immune responses against infected hepatocytes and can inhibit the HBV entry in hepatocytes up to 90% when cells are treated with IL-6 resulting in a marked reduction in cccDNA and HBsAg secretion [74]. The gene discussed is IL6; the disease is viral infectious disease.