To confirm the correlation of the SNHG16/miR-302b-3p/SLC2A4 axis with PC progression, PC cells with stable silencing of SNHG16 were transfected with the miR-302b-3p inhibitor, miR-302b-3p inhibitor plus sh-SLC2A4, or NC inhibitor, and the biological phenotypes of these PC cells were analyzed. This evidence concerns the gene SLC2A4 and pachyonychia congenita.