Likewise, extensive lung infection by SARS-CoV-2 in COVID-19, triggers capillary leakage which if sustained may lead to viremia (i.e., the presence of infectious virus in the circulation), local over-activation of the ACE/ANGII/AT1R signaling due to ACE2 diminishment, extensive inflammation and the so-called “cytokine storm” (Fig. 2a). This evidence concerns the gene ACE and COVID-19.