Moreover, HBV-T cells secret fewer IFN-γ and TNF-α but more IL-6 and IL-10 than NC-T cells, while amygdalin pretreatment could rescue IFN-γ and TNF-α production and reduce IL-6 and IL-10 production, indicating that amygdalin could play a role in the development of HBV-related HCC through acting on T cell-mediated tumor immunity. This evidence concerns the gene IL6 and hepatocellular carcinoma.