CD4 and neoplasm: Lactobacillus casei BL23 could improve immune response by reducing TReg level in mice with colitis-associated cancer;118 and Lactobacillus plantarum prolonged survival of tumor-bearing mice by enhancing effector Cd8 + T cells functions, Cd4 + T cells differentiation, and NK cells intratumoural infiltration.119 In a trial probiotics (Lactobacillus acidophilus NCFM and Bifidobacterium lactis BI-04) were given to 15 CRC patients (NCT03072641,120).