involving B. breve and B. longum to TAC mice was sufficient to improve dendritic cell-mediated immune responses (e.g. increased level of interferon-γ, accumulation of peripheral tumor-specific T cells, and intratumoral Cd8 + T cells), leading to ameliorated tumor control to the same extent as anti-PD-L1 antibodies, whereas combining both treatments almost abolished all tumor growth. The gene discussed is CD274; the disease is neoplasm.