Notably, administration of A. muciniphila to microbiota-depleted mice with fecal transplantation from nonresponders stimulated Il-12-dependent infiltration of Ccr-9+ Cxcr-3+ Cd4 + T cells into tumor beds, resulting in the restoration of the anticancer effect of PD-1 blockade.30 This evidence concerns the gene PDCD1 and neoplasm.