CD4 and neoplasm: For example, resveratrol in grapes could enhance anticancer immunity in tumor-bearing mice by making TIM unfavorable for tumor growth (e.g. promoting accumulation of effector Cd8 + T cells and monocytic myeloid-derived suppressor cells (MDSCs), and inhibiting the population of tumor-derived Cd4+ Cd25+ TReg and Cd8 + T cell-suppressing granulocytic MDSCs97–99).