We have also shown that Akt inhibitor IL-6-Hydroxymethyl-chiro-inositol 2-(R)-2-O-methyl-3-O-octadecylcarbonate induces MM cell death associated with downregulation of the NF-κB activity, suggesting crosstalk between PI3K-Akt and NF-κB signaling pathways [85]. The gene discussed is NFKB1; the disease is Miyoshi myopathy.