In an analysis carried out by The Cancer Genome Atlas Research Network on 316 patients affected by HGSOC, BRCA1 and BRCA2 germline mutations were identified in 9% and 8% of cases, respectively, and an additional 3% showed somatic mutations of the BRCA genes, for a total of 20% of HGS ovarian carcinomas exhibiting a BRCA mutation. The gene discussed is BRCA1; the disease is ovarian carcinoma.