WFDC2 and ovarian carcinoma: Whereas, the level of HE4 higher than 66 pmol/L after the third cycle of chemotherapy seems to be a good prognostic marker to identify those patients who will develop a relapse of the ovarian cancer (sensitivity = 78.26; specificity = 91.3; AUC = 87%, p value < 0.001; LR+ = 8.99; Post-test probability = 85%) (Figure 3).