WFDC2 and ovarian carcinoma: It should show that, in the BRCA population, a level of HE4 higher than 65.6 pmol/L after the 3rd cycle of chemotherapy seems to be a good prognostic marker to identify patient who will develop a relapse of ovarian cancer (sensitivity = 75; specificity = 99; AUC = 92%, p value < 0.001; LR+ = 750; Post-test probability = 99%).