In several hematological malignancies, such as CLL [13], diffuse large B-cell lymphoma (DLBCL) [14], mantle cell lymphoma (MCL) [15] and follicular lymphoma (FL) [16], SYK acts as a proto-oncogene and is thus involved in tumorigenesis. The gene discussed is SYK; the disease is B-cell chronic lymphocytic leukemia.