Indeed, Goodman et al. reported a SYK deficiency in pediatric precursor pro-B-ALL [18], whereas Perova et al. demonstrated in pediatric and adult B-ALL samples a pre-BCR independent SYK activation in high-risk precursor B-ALL patients and with that an apoptosis induction by specific SYK inhibition [19]. The gene discussed is SYK; the disease is acute lymphoblastic leukemia.