Beyond the cardiac properties, SPARC has roles in the cardiovascular properties, as suggested by its production by both bone-marrow-derived cells during myocardial fibrosis (in left ventricular pressure overload) [64] and pericytes, with a possible role in postinfarct healing [65], which is supported by the possible classification of SPARC as a marker for vascular complications in pre-diabetics [66]. Here, SPARC is linked to Myocardial fibrosis.