These genes included Wnt signal-related, IGF signal-related, interferon-related, mTOR-related, and cell cycle-related genes known to be involved in the process of carcinogenesis of hepatocellular carcinoma, in addition to the retinoid-related genes which are the targets of peretinoin, suggesting that peretinoin directly or indirectly regulate many signal transduction systems in the carcinogenic process. Here, IGF1 is linked to hepatocellular carcinoma.