High levels of ExVs containing miR-21 and miR-27 were measured in the plasma of patients with oral squamous cell carcinoma (OSCC) cancer by Momen-Heravi et al. Uptake of these ExVs by monocytes activated the NF-κB pathway and established a pro-inflammatory and pro-tumorigenic milieu associated with increased levels of IL-6, C-C motif chemokine ligand 2 (CCL2), prostaglandin E2 and matrix metallopeptidase MMP 9. The gene discussed is CCL2; the disease is oral cavity squamous cell carcinoma.