Beyond host-virus infection, a study by Sadat et al. examining a rare genetic disease (type II congenital disorders of glycosylation (CDG-IIb)), caused by mutation in the gene encoding N-linked glycan processing enzyme mannosyl-oligosaccharide glucosidase (MOGS), reported that despite severe hypogammaglobulinemia, the patients did not show susceptibility to viral infection or recurrent infections, indicating a potential role of glyco-machinery in directly impacting an individual’s degree of susceptibility to enveloped viruses [14]. Here, MOGS is linked to MOGS-congenital disorder of glycosylation.