The second top miRNA is mir-92a-3p, which has involvement in several pathological conditions: it is a potential oncomir [158,268], overexpression creates resistance to the TRAIL-dependent apoptosis by suppressing MYCBP2 in melanoma [158], promotes the progression of liposarcoma by stimulating the tumor-associated macrophages to secret IL6, a proinflammatory cytokine [159], promotes tumorigenesis in glioma cells by regulating cadherin 1 (CDH1)/β-catenin signaling but at the same time reduces the stemness of glioma stem cells (GSCs) by modulating Notch-1/Akt signaling [160]. This evidence concerns the gene AKT1 and central nervous system cancer.