SIX1 and cancer: In cancer, miR-186-5p showed both anti- and pro-cancer roles; for example, it shows anti-tumor properties in osteosarcoma by targeting FOXK1 [195] and TBL1XR1 [196], in colorectal cancer by targeting ZEB1 [197], in NSCLC by targeting SIX1 and in neuroblastoma by downregulating Eg5 [198], while it promotes lung adenocarcinoma by targeting PTEN [199] and metastatic prostate cancer [200].