In cancer, miR-92b-3p have both anti- and pro-cancer roles in different types of cancers: it suppresses pancreatic cancer by targeting GABRA3 [252], but promotes several others such as colorectal cancer by inhibiting FBXW7 [253], esophageal squamous cell carcinoma by target KLF4 and DCS2 [254], gastric cancer by downregulating MMP2, MMP9 and HOXD10 [255], and also could be a biomarker for synovial sarcoma [256]. The gene discussed is KLF4; the disease is cancer.