RPS14 and myelodysplastic syndrome associated with isolated del(5q): 5q-syndrome is a type of anemia that is caused by the haplo-insufficiency of RPS14 [73], a critical component for 40S assembly, and depletion of RPS14 in human CD34+ cells is sufficient to recapitulate the 5q-defect of erythropoiesis with sparing of megakaryocytes [91].