TRAF3 and plasma cell myeloma: In the terminal stage of myeloma, homozygous deletion of the genes associated with inhibition for the NF-kB pathways is detected (10–15% in total), including baculoviral IAP repeat containing protein 2/3 (BIRC2/3) on chromosome 11 (~7%), TNF receptor-associated factor 3 (TRAF3) on chromosome 14 (~3%) and cylindromatosis (CYLD) on chromosome 16 (~3%) [133].