This may reflect the fact that germline ALL-predisposing SNPs, including those involving CDKN2A/B, IKZF1 and PAX5, sustain a pre-leukemic environment favoring the appearance of primary genetic lesions that lead to leukemia, instead of causing the appearance of a specific rearrangement/genetic primary abnormality, at least when referring to CDKN2A/B-related germline variants [105]. This evidence concerns the gene CDKN2A and acute lymphoblastic leukemia.