We observed overrepresentation of the Onc2.3-Pan-TSG-Drivers among the top 1% of all known biological processes with statistically significant enrichment in known pathways involved in cancer initiation and progression, including AR, EGF/ERGR, TGF-beta, PDGFB, mTOR, and VEGF signaling pathways, ubiquitin mediated proteolysis, chromatin modifying enzymes and organization, and RHO GTPase effectors (Table S22). The gene discussed is MTOR; the disease is cancer.