Then, diallyl trisulfide (DATS), known as one of the main ingredients of galic, suppressed interaction of Trx1 and downstream nuclear factor kappa B. Of note, a small molecular PX12 that covalently bind to non-catalytic Cys73 of Trx1 has failed in phase II trials for pancreatic cancer due to lack of significant anti-tumor activity [27]. This evidence concerns the gene TXN and familial pancreatic carcinoma.