MAP3K5 and cancer: In this paper, we demonstrated LH induced ROS accumulation by suppressing Trx1 and TrxR through binding to the Cys32/Cys35 residues of Trx1 redox sites and alkylating the C-terminal redox-active site Sec498 of TrxR, resulting in ASK1/JNK signal activation and apoptosis in cancer cells.