Of particular interest, several transcription factors and co-activators such as the cyclic adenosine monophosphate (cAMP) response element-binding protein (CREB), CREB- regulated transcription coactivator-1 (CRTC1), and nuclear factor-kappa-light-chain-enhancer of activated B cells (NF-κB), have been related to AD. Here, CRTC1 is linked to Alzheimer disease.