AD pathological hallmarks, comprising accumulation of amyloid-β peptide (Aβ) aggregates forming extracellular plaques, and hyperphosphorylated species of tau microtubule-associated protein, forming intraneuronal neurofibrillary tangles (NFTs) are known to follow an anatomical-temporal pattern starting in the temporal lobe and spreading to neocortical areas at later stages [6,7]. The gene discussed is MAPT; the disease is Alzheimer disease.