IGF1 and Alzheimer disease: miR-206 is also able to regulate insulin like growth factor 1 (IGF1) [114]; likewise, miR-26b was associated with an increase in Aβ production through inhibition of IGF1 translation in vitro [97] regulate neprilysin (NEP), a type II transmembrane glycoprotein found on the pre-synaptic membrane and which downregulation has been linked to Aβ increased levels in mice AD model [99].