AGER and systemic lupus erythematosus: It is our proposition that the two most interesting diseases that can prove useful on such note would be systemic lupus erythematosus and systemic scleroderma, since both diseases have characteristic phases (acute, subacute, and chronic), which can better define the already discussed roles of AGE (mostly in chronic conditions) and AOPP (most prominent in acute processes) and their interaction with RAGE.