Concerning the same mechanism, it is noteworthy that de Carvalho et al. investigated the role of RAGE in lichen planus, observing that its levels were more prominent in the upper layers of the dermis of patients compared with healthy controls, even though the levels of its mRNA were lower: they suggested that this might be due to the rapid translocation of HMGB1 by affected keratinocytes [37]. The gene discussed is AGER; the disease is lichen planus.