MAPK3 and atopic eczema: On the same note, but regarding atopic dermatitis, there is a study focusing on the role of quercetin in inhibiting the RAGE pathway through HMGB1 [38]: in this study, the authors observed downregulation of cytoplasmic HMGB1, RAGE, nuclear p-NFκB, p-ERK1/2, COX2, TNFα, IL-1β, IL-2Rα, IFNγ, and IL-4 and upregulation of nuclear Nrf2, which ultimately resulted in an attenuation of the atopic dermatitis-like lesions induced by a house dust mite extract applied to the dorsal skin of NC/Nga transgenic mice.