TNF and ulcer disease: In detail, correlation was observed with skin fibrosis, scars, ulcers, pulmonary fibrosis, and, at a molecular level, serum levels of anti-topoisomerase 1 antibodies, IgG, CRP (C reactive protein), and ESR (erythrocyte sedimentation rate), but not TNF-α, IL-1β, and IL-6 [52], even though another study, concerning calcinotic deposits, did not produce such clear cut results [53].