To better understand the role of AIFM3 overexpression in cholangiocarcinoma, the authors explored the protein–chemical interaction networks and found that AIFM3 linked to various key molecules in cancer progression through z-VAD-fmk, which is a pan-caspase inhibitor widely used to block apoptosis [27]. The gene discussed is AIFM3; the disease is cholangiocarcinoma.