VEGFA and neoplasm: On the contrary, “alternatively activated” or M2 macrophages, in which tumor-associated macrophages (TAMs) are included, play an immunosuppressive role that facilitates tumor progression and are characterized by high expression levels of scavenging (CD163) and mannose (CD206) receptors, arginase and the production of IL-10, VEGF and matrix metalloproteinases (MMP).