Another important factor is the soluble major histocompatibility complex class I-related chain A (MICA), liberated by shedding from the MM cell surface, which downregulates Natural Killer receptor group 2 member (NKG2D) expression in NK and T cells and is a prognostic factor for the overall survival (OS) and PFS of MM patients [227,228]. The gene discussed is MICA; the disease is Miyoshi myopathy.