Using this approach, we observed coding mutations in tumour-suppressor genes usually required for normal chromatin remodelling, including ARID1A (AT-rich interaction domain 1A gene), BRD3 (Bromodomain-containing protein 3 gene), and SMARCA4 (SWI/SNF-Related Matrix-Associated Actin-Dependent Regulator of Chromatin Subfamily A, Member 4 gene). The gene discussed is SMARCA4; the disease is neoplasm.