VEGFR (Vascular Endothelial Growth Factor Receptor) and PI3K/AKT/mTOR (Phosphatidyl-Inositol-3′-Kinase/Protein Kinase B/Mammalian Target Of Rapamycin) emerged as two major pathways involved in ccRCC carcinogenesis. The gene discussed is AKT1; the disease is nonpapillary renal cell carcinoma.