After examining the correlation between recurrence and insulin resistance, glycolipid metabolism, stress, inflammation, and serum p53 concentration after radical surgery in 80 patients with esophageal cancer who underwent surgery, Zheng et al. concluded that complex hypertension, hyperlipidemia, and diabetes mellitus were independent risk factors for postoperative recurrence of esophageal cancer. The gene discussed is TP53; the disease is esophageal cancer.