Furthermore, it was disclosed that the inclusion of sex steroids and hormones, such as dehydroepiandrosterone sulfate, estradiol, testosterone, estrone, sex hormone-binding globulin (SHBG), IGF-I, IGF-binding protein 3, or prolactin, might improve the prediction of risk for invasive breast cancer for pre- and postmenopausal women [91]. This evidence concerns the gene SHBG and invasive breast carcinoma.