In a study by Giussani et al. [86], plasma samples from healthy controls and patients with malignant or benign breast disease were tested for the expression of extracellular matrix (ECM) molecules, collagen 11a1 (COL11A1), collagen oligomeric matrix protein (COMP), and collagen 10a1 (COL10A1). The gene discussed is COL11A1; the disease is breast fibrocystic disease.