SEREX was also used to identify a combination of six antigens: RAD50 double-strand break repair protein (RAD50), par-3 family cell polarity regulator (PARD3), secreted phosphoprotein 1 (SPP1), SAP30 binding protein (SAP30BP), kinesin family member 15 (NY-BR-62), and NY-CO-58, which could differentiate breast cancer patients from healthy subjects [89]. This evidence concerns the gene SPP1 and breast cancer.