In order to ascertain the optimal dose of A. bisporus, or white button mushroom (WBM), to achieve in humans the effects of suppressing aromatase activity and inhibiting breast cancer cell proliferation already established in vitro and in preclinical tests, Palomares et al. [114] carried out the following dose-finding study: a 12-week course of treatment with 5, 8, 10, or 13 g daily of the fungal extract in postmenopausal women previously diagnosed with breast cancer but no longer undergoing treatment and who are recurrence free. Here, CYP19A1 is linked to breast cancer.