When the D-fraction (β-glucan) of G. frondosa was tested in patients with cancer (lung, lingual, breast, gastric, or liver cancer), inhibition of the progression of metastasis was observed and a reduced expression of tumor markers (carcinoembryonic antigen (CEA) and cancer antigen 15–3 (CA15–3) and CA19–9) [70]. The gene discussed is CEACAM5; the disease is liver cancer.