DDIT3 and ischemic stroke: This metabolite was also found to be effective against ischemic stroke, as reported in a study on rats in which the reduction of neuronal apoptosis, as well as the size of the stroke cavity in the brain by targeting iNOS/reactive nitrogen species (RNS) and p38 mitogen-activated protein kinase (MAPK)/CCAAT enhancer-binding protein homologous protein (CHOP) pathways, was observed [46].