Ganopoly®, administered at doses of 1800 mg/d three times daily for 12 weeks in 34 advanced lung cancer patients, also had positive effects on immunological functions, producing significant increases in plasma IL-2, IL-6, and IFN-γ concentrations, Cd56+, phytohemagglutinin (PHA) responses, and NK activity, as well as significant decreases in IL-1 and TNF-α [83]. This evidence concerns the gene IFNG and lung carcinoma.