Tualang honey ameliorated breast cancer by increasing the susceptibility of proapoptotic proteins; apoptotic protease activating factor-1 (Apaf-1) interferon-gamma (IFN-γ) interferon gamma receptor-1 (IFNGR1) tumor protein P53 (p53) and decreased the expression of anti-apoptotic proteins; tumour necrosis factor alpha (TNF-α), cyclooxygenase-2 (COX-2) and B-cell lymphoma-extra-large (Bcl-xL). The gene discussed is APAF1; the disease is breast carcinoma.