IDH1 and central nervous system cancer: Moreover, CD73 overexpresses in gliomas with isocitrate dehydrogenase-1 (IDH1) mutation, and studies proposed that the CD73 overexpression in peripheral blood mononuclear cells (PBMCs) of glioma patients can be a diagnostic factor for IDH1-mutated glioma in cases where biopsy or surgery are not feasible [55].