-Overexpression is associated with poor prognosis, and reduced overall survival by 27% [58,59,61,62,104,111,124]-Serves as a prediction factor of treatment response to ICI, chemokine receptor blockade, and chemotherapy [104,137,138]-Downregulation is a favorable prognostic factor in DFS [62]-CD73 overexpression in PBMCs could be diagnostic factor in IDH-1 mutated glioma patients [55]-Prognostic biomarker for overall survival and response to treatment in mesenchymal-GBM patients [59]-CD73+ EVs could be a diagnostic/prognostic factor in GBM [129,130]. The gene discussed is NT5E; the disease is central nervous system cancer.