PDZK1IP1 and calcification: Intriguingly, we found that a high LA calcium score correlated with high SPAP (Figure 3C), and SPAP was significantly higher in patients with severe LA calcification compared with those without LA calcification (65.7 ± 19.5 vs. 51.3 ± 13.9 mmHg; p = 0.045) (Figure 3D).