A variety of heritable skeletal conditions is associated with dysregulated TGF-β signaling, including Camurati-Engelmann disease [MIM: 131300] [67], Marfan syndrome [MIM: 154700] [68] and Loeys-Dietz syndrome [MIM: 613795] [69] but also OI [70]. This evidence concerns the gene TGFB1 and osteogenesis imperfecta.