Moreover, it was noted that miR-488-5p is downregulated in melanoma and that the ectopic introduction of miR-488-5p was determined to induce apoptosis and inhibit anchorage-independent cell growth via targeting DIX domain-containing 1 (DIXDC1) [160], a pro-survival and -metastatic factor [190,191,192] (Figure 2 and Table 2). The gene discussed is DIXDC1; the disease is melanoma.