In fact, CD44 or homing cell adhesion molecule (HCAM), a cell membrane glycoprotein, which interacts with different BMM-associated proteins such as hyaluronan, osteopontin or E-selectin, was shown to be crucial for CML and the engraftment of CML cells [51]. The gene discussed is SPP1; the disease is chronic myelogenous leukemia, BCR-ABL1 positive.