AKT1 and chronic myelogenous leukemia, BCR-ABL1 positive: Similarly, PI3K/AKT signaling has been shown to have a key role in CML, mediating both the activation of cell survival [63] and possibly anti-apoptotic signaling [64], whereas the activation of Ras/MAPK signaling has been implicated in BCR-ABL1-dependent cellular transformation [65].