DYRK2 and leukemia: In addition, the zinc finger transcription factor Krüppel-like factor 4 (KLF4) maintains leukemia-initiating cells’ (LIC) survival and self-renewal capacity via downregulation of the dual-specificity tyrosine-(Y)-phosphorylation-regulated kinase 2 (DYRK2), which in turn reduces c-Myc protein levels and activates p53.