TP53 and chronic myelogenous leukemia, BCR-ABL1 positive: The inhibition or knockdown of SIRT1 induced apoptosis in CML LSC via p53 [133] and impeded CML induction by reducing the expression of mitochondrial genes in CML stem and progenitor cells, while the combination of a TKI with Sirt1 deletion further suppressed CML progression [134].