INS and obesity due to melanocortin 4 receptor deficiency: Adipose tissue remodeling as a response to changes in nutrient excess in obesity, followed by adipocyte hypoxia and enhanced chemokine secretion, leads to NLRP3-mediated adipose tissue inflammation, which ultimately results in the impairment of the insulin signaling pathway and insulin resistance, the primary causative factors in the development and manifestation of metabolic syndrome.