Adipose tissue remodeling as a response to changes in nutrient excess in obesity, followed by adipocyte hypoxia and enhanced chemokine secretion, leads to NLRP3-mediated adipose tissue inflammation, which ultimately results in the impairment of the insulin signaling pathway and insulin resistance, the primary causative factors in the development and manifestation of metabolic syndrome. The gene discussed is NLRP3; the disease is Insulin resistance.