Vandanmagsar et al. reported a crucial role of NLRP3 in this obesity-induced inflammatory disorder where metabolic DAMPs, such as excess ATP, glucose, ceramides, reactive oxygen species, oxidized LDL, uric acid, as well as crystals of cholesterol and monosodium urate, leads to NLRP3 and IL-1β mediated pro-inflammatory response. This evidence concerns the gene NLRP3 and obesity due to melanocortin 4 receptor deficiency.