Most frequently mutated genes of the pathway are the co-receptor LRP1B (LDL receptor related protein 1B) and the FAT type cadherins FAT4 and FAT1, which have all a prevalence of mutations in PIK3CA mutated cancers of 13.4%, while in the non-mutated group they are mutated in 10%, 3.3%, and 7.8% of cases, respectively (Figure 5). The gene discussed is FAT4; the disease is cancer.