APP and dementia: In this context, it is worth mentioning that several genes linked to dementia, including APP, PSEN1, PSEN2, and ITM2b, play a physiological role in glutamatergic transmission and that mutations linked to familial dementia alter this physiological functions (16, 26, 27, 28, 29, 30, 31, 32, 33, 34, 35, 36, 37, 38, 39, 40, 41).