In this context, it is worth mentioning that several genes linked to dementia, including APP, PSEN1, PSEN2, and ITM2b, play a physiological role in glutamatergic transmission and that mutations linked to familial dementia alter this physiological functions (16, 26, 27, 28, 29, 30, 31, 32, 33, 34, 35, 36, 37, 38, 39, 40, 41). This evidence concerns the gene PSEN1 and dementia.